Psoriasis protein deficiency, Psoriasis serdülők | Sanidex Magyarországon


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J Bone Miner Res ; 27 11 :Nov. By binding to the extracellular matrix protein collagen X and matrix vesicles, annexins were proposed to anchor matrix vesicles in the extracellular space of hypertrophic chondrocytes to initiate the calcification of cartilage.

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However, mineralization appears to be normal in mice lacking AnxA5 and AnxA6, whereas collagen X-deficient mice show only subtle alterations in the growth plate organization. We hypothesized that the simultaneous lack of Psoriasis protein deficiency, AnxA6, and collagen X in vivo induces more pronounced changes in the growth plate development and the initiation of mineralization.

Surprisingly, mice were viable, fertile, and showed no obvious abnormalities.

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Hence, collagen X is needed for hematopoiesis during endochondral ossification and for the immune response, but the interaction of annexin A5, annexin A6, and collagen X is not essential for physiological calcification of growth plate cartilage. Therefore, annexins and collagen X may rather fulfill functions in growth plate cartilage not directly linked to the mineralization process.

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